Osteolysis disease is a condition that occurs when certain types of particles, usually microscopic pieces of plastic, ceramic, or metal, come off of a knee or hip implant due to wear and tear. This then causes the immune system to produce a reaction that causes living bone tissue to be reabsorbed by the body. Osteolysis disease can also lead to the formation of holes in the bones, which can then cause severe weakness of the bones. When this happens, implants become loose, and bones begin to break. Patients who develop this condition because of a knee or hip implant typically require surgery to correct the issue.

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